Amberen's Clinical Trials

Type of Study Human Clinical Trials
Protocol Randomized, double blind, placebo-controlled, cross over clinical trials.
Results Excerpt from Amberen Clinical Trial Report. "Amberen-based monotherapy significantly lowered most subjectively evaluated characteristics of menopausal syndrome. Amberen monotherapy also alleviated symptoms of some neurovegetative and psycho-emotional disorders, such as hot flushes, headache, and anxiety."
Adverse
Side Effects		 No side effects registered
Peer-reviewed
Publications		 (2008) A Succinate-Based Composition Reverses Menopausal Symptoms Without Sex Hormone Therapy. Advances in Gerontology, Vol. 21, No. 2, pp. 298-305.

Click here to view abstract on Pubmed.gov

(2007) A Succinate-Based Composition "Rejuvenates" Aging Mice and Alleviates Menopausal Symptoms in Women Without Sex Hormone Replacement Therapy. Medline (Gerontology, Endocrinology), Vol. 8, Art. 46, pp. 497-517.

Click here to read full article

(2005) Succinate-Based Preparation Alleviates Manifestations of the Climacteric Syndrome in Women. Bulletin of Experimental Biology and Medicine (Pharmacology, Toxicology), Vol. 140, No. 3, pp.
312-314.

 Click here to view abstract
natural-menopause-relief
Type of Study Five-year Clinical Study of 32 Menopausal Women
Protocol Randomized, Placebo Controlled
Results Amberen alleviated symptoms of menopause when administered as monotherapy. In women who were undergoing electro-acupuncture treatment (EAT), adding Amberen to the regimen showed optimized results from the EAT.
Adverse
Side Effects		 No side effects registered
natural-menopause-relief
Type of Study Animal Study
Protocol Evaluation of four-week Amberen treatment on the estral cycle, bone mass and calcium content of aging mice.
Results Amberen therapy alleviated many biochemical symptoms of menopause in aging mice.

"The administration of SBC to aging mice had a favorable effect on the appearance and behavior of animals—they became more active, their lackluster eyes acquired brightness, and the pale, yellowish coat regained white color and shine, resembling the coat of young animals. The bald skin spots grew new hair."
Peer-reviewed
Publications 		No side-effects registered
natural-menopause-relief
Type of Study Animal Study
Protocol Six-week laboratory study of biochemical effects of Amberen treatment in old female rats.
Results Amberen corrects ovulation cycle in old female rats.
Peer-reviewed
Publications		 Manuscript is being prepared for submission to a peer-reviewed publication

Lunada Biomedical is a science-based company.

Our drug-free formulations are based on decades of research conducted by world-renowned scientists. Behind every product you’ll find years of testing and published scientific research by V. M. Dilman, M. N. Kondrashova, E. I. Maevsky, M. L. Uchitel, A. B. Peskov and V. I. Heifets. Our focus is simple: identify the triggers that accelerate aging and develop technologies that slow these mechanisms down. This research is the scientific backbone of our NAS platform. The list below contains dozens of articles authored by the above referenced scientists and published in peer-reviewed journals over the last few decades, as well as several presentations (Gastro-2007 in Saint-Petersburg, Russian National Congresses “Man and Drug” in Moscow and 5th annual Assay and Drug Discovery Technologies Conference held on September 20-21, 2010 in San Diego, CA) made by our scientific team.

test Age-associated elevation of hypothalamic threshold to feedback control, and its role in development, ageing, and disease. V. M. Dilman. The Lancet, June 12, 1971, 1211-1219.
test Accumulation and utilization of amber (succinic acid) in mitochondria. M. N. Kondrashova, Nauka, Moscow, 151-169, 1972. Original title: "Накопление и использование янтарной кислоты в митохондриях".
test Biochemical cycle of excitation. M. N. Kondrashova. Biological and Biochemical Oscillators. Academic Press, New York-London, B. Chance, Editor, 373-389, 1973.
test The effect of amber (succinic) and glutamic acids on the sensitivity of hypothalamo-gonadotropic system in old rats. V. M. Dilman, V. N. Anisimov, M. N. Kondrashova. Pharmacology and Toxicology, Moscow, 3, 540, 1976. Original title: "Влияние янтарной и глутаминовой кислот на чувствительность гипоталамо-гонадотропной системы к ингибирующему действию эстрогенов у старых крыс".
test Therapeutic action of amber (succinic) acid. M. N. Kondrashova. ONTI Pushchino, 1976. Original title: "Терапевтическое действие янтарной кислоты".
test Does succinic acid mediate adrenaline stimulation in mitochondria? E. I. Maevsky, I. B. Guzar, A. S. Rosenfeld, M. N. Kondrashova. EBEC Reports, LBTM-CNRS, Lyon, 2, 537, 1982.
test Succinic acid as the only energy support of intensive Ca2+ uptake by mitochondria. M. N. Kondrashova, V. G. Gogvadze, A. M. Babsky. Biochemical and Biophysical Research Communications, 109, 2, 376-381, 1982.
test Effect and after-effect of adrenalin on the respiration of rat liver mitochondria. A. M. Babsky, M. N. Kondrashova, I. V. Shostakovskaya. Physiology Journal, Kiev, 31, 301-306, 1985. Original title: "Действие и последействие адреналина на дыхание митохондрий".
test Changes in stimulation of mitochondria respiration by adrenaline depending on the dose. M. N. Kondrashova, A. M. Babsky. Ukranian Biochemistry Journal, 58, 6, 49-54, 1986. Original Title: "Изменение стимуляции дыхания адреналином в зависимости от дозы".
test Activation of a-ketoglutarate oxidation by acetylcholine. I. V. Shostakovskaya, N. M. Doliba, A. M. Babsky, M. N. Kondrashova. Ukranian Biochemistry Journal, 58, 6, 54-61, 1986. Original title: "Активация ацетилхолином окисления-кетоглутарата в митохондриях печени".
test Heat production in mitochondria during oxidation of different substrates. M. N. Kondrashova, E. V. Grigorenko, E. P. Khizhnyak. Biophysics, Moscow, 33, 3, 527-523, 1988. Original title: "Теплопродукция в митохондриях при окислении разных субстратов".
test Rapid cycle of substrate oxidation under activation of energy metabolism. M. N. Kondrashova, E. V. Grigorenko, E. A. Kosenko. The 5th EBEC, Aberystwyth 287, 1988.
test Polarographic observation of substrate-level phosphorylation and its stimulation by acetylcholine. M. N. Kondrashova, N. M. Doliba. FEBS Letters, Volume 243, 153-155, 1989.
test Structural-kinetics organization of tricarboxylic acid cycle under active functioning of tissues. M. N. Kondrashova. Biophysics, Moscow, 34, 3 450-458, 1989. Original title: "Структурно-кинетическая организация цикла трикарбоновых кислот при активном функционировании ткани".
test Interaction of transamination and oxidation of carboxylic acids. M. N. Kondrashova. Biochimia, Moscow, 56, 388-406, 1991. Original Title: "Взаимодействие процессов переаминирования и окисления".
test Succinic acid as a physiological signal molecule. In: Signal Molecule and Behavior. M. N. Kondrashova, S. P. Volkova, I. V. Kuznetzov, E. V. Grigorenko, A. M. Babsky, A. Podoletz, G. D. Kuznetzova, (W. Winlow, O. S. Vinogradova, D. A. Sakharov, eds.). Manchester University Press, Manchester & New York, 1991, 295-300.
test Preventive remedy for prenatal pneumopathy of newborns induced by intrauterine hypoxia and infections. M. N. Kondrashova, А. А. Аnanenko, N. А. Fedyushkina, N. V. Кleimenova, I. V. Pasynkov, О. D. Viduta. Patent, Russian Federation, #2056842, 27.03.1996. Original title: "Средство для внутриутробной профилактики пневмопатий новорожденных, вызванных внутриутробной гипоксией и инфекцией".
test Biochemical substantiation of practical application of metabolites in the correction of hypoxic states during parenteral and enteral nutrition. E. I. Maevsky, V. M. Vereshagina, E. V. Grishina, A. S. Rosenfield. Sklifosofsky Emergency Care Research Institute, 1997. Original title: "Биохимическое обоснование практического использования метаболитов в корреекции гипоксических состояний при проведении парентерального и энтерального питания".
test Amber (succinic) Acid in Medicine, Food industry and Agriculture. Editors: M. N. Kondrashova, U. G. Kaminsky, E. I. Maevsky. ONTI, Pushchino, 1996. Original title: "Янтарная кислота в медицине, пищевой промышленности, сельском хозяйстве".
test Method to stimulate vital activity of farm-raised birds. M. S. Naidensky, I. S. Shpits, К. V. Luzbaev, М. N. Кondrashova, U. М. Goldberg, E. М. Khrabrova, I. V. Savelieva, V. A. Eidelman. Patent, Russian Federation, #2102063, 20.01.1998. Original title: "Способ стимуляции жизнедеятельности сельскохозяйственной птицы".
test Eye drops Pyrotonic. S. А. Borzenok, Z. I. Моroz, S. U. Shemakin, М. N. Коndrashova. Patent, Russian Federation, #2127100, 10.03.1999. Original title: "Глазные капли – ПИРОТОНИК".
test Method to reduce toxic effect of high doses of vitamin D2 in children with D-resistant rachitis using amber acid. А. А. Аnanenko, М. N. Коndrashova, О. N. Safronova, P. V. Novikov, N. V. Кlemenova, E. А. Yurieva. Patent, Russian Federation, #2125449, 27.01.1999. Original title: "Способ снижения токсического воздействия высоких доз витамина D2 у детей с витамин D-резистентным рахитом путем применения янтарной кислоты".
test Formula that reduces alcohol intoxication, prevents and relieves alcohol intoxication and hangover syndrome. E. I. Мaevsky, М. N. Коndrashova, М. L. Uchitel. Patent, Russian Federation, #2160589, 20.12.2000. Original title: "Средство для снижения алкогольного опьянения, предупреждения и снятия алкогольной интоксикации и похмельного синдрома и способ для снижения алкогольного опьянения, предупреждения и снятия алкогольной интоксикации и похмельного синдрома с помощью этого средства".
test Substantiation for the application of succinate-based dietary supplements Yantavit and Mitomin. E. I. Маевский, Е. V. Grishina, А. S. Rosenfield. Journal of International Academy of Authors of Scientific Discoveries and Inventions, December 2000. Original title: "Обоснование использования биологически активных добавок Янтавит и Митомин на основе янтарной кислоты".
test Mechanisms of physiological activity and curative effect of small doses of succinic (amber) acid. M. N. Kondrashova. European Journal of Medicine, Res. 5, 28, 2000.
test Anaerobic Formation of Succinate and Facilitation of Its Oxidation: Possible Mechanisms of Cell Adaptation to Oxygen Deficiency. Е. I. Маevsky, Е. V. Grishina, А. S. Rosenfield, А. М. Zyakun, М. N. Коndrashova, V. М. Vereshyagina. Biophysics, 2000, volume 45, # 3, 509-513. Original title: "Анаэробное образование сукцината и облегчение его окисления - возможные механизмы адаптации клетки к кислородному голоданию".
test Mitochondria in Pathology. Editors: M. N. Kondrashova, U. G. Kaminsky, E. I. Maevsky. ONTI Pushchino, 2001. Original title: "Митохондрии в патологии".
test Correction of metabolic acidosis through sustaining of mitochondrial function. E. I. Maevsky, А. S. Rosenfield, Е. V. Grishina, М. N. Коndrashova. ONTI Pushchino, 2001. Original title: "Коррекция метаболического ацидоза путем поддержания функций митохондрий".
test Biological activity of amber acid. Е. I. Маevsky, М. N. Коndrashova, М. L. Uchitel, P. P. Garyaev, G. G. Tertyshny, А. М. Yaroshenko, А. V. Mologin, А. V. Shabelnikov, Е. А. Leonova, V. I. Heifets, D. B. Borzov, B. I. Birshtein. Medicina Altera, December 2001, 6, 11-12. Original title: "Биологическая активность янтарной кислоты".
test The reasoning behind application of dietary supplements based on metabolic substrates. E. I. Maevsky, А. S. Rosenfield, Е. V. Grishina, М. N. Коndrashova, L. А. Bogdanova. Russian Journal of gastroenterology, hepatology and coloproctology, 2001, volume XI, #4, 22-28. Original title: "О целесообразности применения пищевых добавок на основе субстратов энергетического обмена".
test Glucose metabolism of healthy patients and patients with deficiencies of carbohydrate and lipid metabolism. Е. I. Sokolov, А. L. Davydov, N. Т. Starkova, А. М. Zyakun, Е. I. Маеvsky, Е. V. Grishina. Human Physiology, 2002, 28(6):115-118. Original title: Глюкозный метаболизм у здоровых пациентов и у больных с нарушениями углеводного и липидного обмена".
test Perspective of medical treatment with amber (succinic) acid in homeopathic doses. M. N. Kondrashova. Mitochondrion 1, 522, 2002.
test Hormone-like action of amber (succinic) acid. M. N. Kondrashova. Problems in Biological Medical and Pharmaceutical Chemistry, volume 1, 7-12, 2002. Original title: "Гормоноподобное действие янтарной кислоты".
test Substrate-hormone system of regulation of physiological state. M. N. Kondrashova, N. I. Fedotcheva, I. R. Saakyan, T. V. Sirota, M. V. Zakharchenko. Horizons in Biophysics, ONTI, Pushchino, 2003, 147-154. Original title: "Субстратно-гормональная система регуляции физиологического состояния. Условия ее выявления. Использование в практике".
test Role of the impairment of oxidative metabolism in pathogenesis of lower urinary tract symptoms with benign prostatic hyperplasia and their treatment by [alpha]1-adrenoblocker alfuzosin. E. L. Vishnevsky, M. N. Kondrashova, D. Y. Pushkar, A. A. Demidov, T. V. Sirota, A. V. Temnov, N. V. Khunderyakova, M. V. Zakharchenko, N. I. Kosyakova. Mitochondrion, 3, 67-73, 2003.
test Method to obtain succinic acid. M. N. Kondrashova, E. I. Maevsky, M. L. Uchitel, T. B. Lyubimova, L.P. Pivonenkova, V. I. Heifets, O. A. Chekova. Patent, Russian Federation, #2237056, 27.09.2004. Original title: "Способ получения янтарной кислоты".
test Composition that helps normalize functional abnormalities occurring during perimenopause and menopause. Е. I. Маеvsky, М. L. Uchitel. Patent, Russian Federation, #2220712, 10.01.2004. Original title: "Средство и набор для нормализации функциональных нарушений, возникающих в предклимактерический и климактерический периоды".
test Inhibition of Krebs cycle and activation of glyoxylate cycle in the course of chronological aging of Saccharomyces cerevisiae. Compensatory role of succinate oxidation. V. Samokhvalov, V. Ignatov, M. Kondrashova. Biochimie, 2004, 86, 39-46.
test Composition with hepatoprotective and antiencephalopathic properties which reduces alcohol intoxication, prevents or inhibits alcohol intoxication and hangover symptoms. Е. I. Маеvsky, М. L. Uchitel, О Khan Do, V. I. Heifets. Patent, Russian Federation, #2254858, 27.06.2005. Original title: "Средство, обладающее гепатопротекторными и антиэнцефалопатическими свойствами, для снижения алкогольного опьянения, предупреждения и снятия алкогольной интоксикации и похмельного синдрома."
test Evidence of the glyoxylate cycle in the liver of newborn rats. I. G. Morgunov, M. N. Kondrashova, S. V. Kamzolova, A. P. Sokolov, N. I. Fedotcheva, T. V. Finogenova. Medical Science Monitor. 2005, 11(2) BR57-60.
test The interaction of Krebs cycle with sympathetic and parasympathetic nervous system. Substrate-hormonal system. M. N. Kondrashova, E. I. Maevsky, E. V. Grigorenko, A. M. Babsky, N. M. Doliba, I. R. Saakyan, T. V. Sirota, N. I. Fedotcheva, V. A. Samokhvalov, International Conference on Mitochondria, from Molecular Insight to Physiology and Pathology. Bari, Italy, 40 Years of Bari Meetings, Dedicated to Ernesto Quagliariello, 74, 2005.
test New Perspectives of Amber Acid in Medicine. Symposium at the XII Russian National Congresses "Man and Drug", 2005, Chairmen E. I. Maevsky, A. G. Chuchalin. Original title: "Новые перспективы янтарной кислоты в медицине".
test Placebo-controlled study of sympathicotonic effects of dietary supplements based on salts of amber acid. А. B. Peskov, Е. I. Маеvsly, М. L. Uchitel, М. N. Коndrashova. Medline.ru., 2005, volume 6, 158, pp. 508-514. Original title: "Плацебо-контролируемое исследование симпатикотонических эффектов биологически активных добавок на основе солей янтарной кислоты".
test Composition of Energy Metabolism Substrates Increases the Efficiency of Pharmacotherapy of Cardiovascular Diseases. A. B. Peskov, Е. I. Маеvsky, М. L. Uchitel. Bulletin of Experimental Biology and Medicine, volume 139, #6, 635-637, June, 2005. Original title: "Повышение эффективности фармакотерапии заболеваний сердечно-сосудистой системы с помощью композиции субстратов энергетического обмена".
test Evaluation of the effectiveness of low-intensity interventions in the clinical history of inner diseases. А. B. Peskov, Е. I. Маеsky, М. L. Uchitel. Ulianovsk State University, 2005. Original title: "Оценка эффективности «малых воздействий» в клинике внутренних болезней".
test The Effect of Succinate on Respiration, Transamination, and Pyruvate Formation in Cells of the Yeast Dipodascus magnusii. A. P. Il'chenko, D. I. Ogorelyshev, N. V. Shishkanova, A. P. Sokolov, T. V. Finogenov, M. N. Kondrashova. Microbiology, Moscow, volume 74, 609-615, 2005. Original title: "Влияние сукцината на дыхание, переаминирование и образование пирувата в клетках дрожжей Dipodascus magnusii".
test New method of laser spectroscopy as the basis for identification of chemical structure of substances. Biological activity of succinic and fumaric acids identified with the method of laser spectroscopy. Е. I. Маеsky, М. L. Uchitel, G. G. Tertyshny, O Khan Do. Pushchino, 2006. Original title: "Новый метод лазерной спектроскопии как основа идентификации тонкой структуры веществ. Биологическая активность идентифицированных методом лазерной спектроскопии янтарной и фумаровой кислот".
test Succinate as geroprotector in the course of chronological aging. V. A. Samokhvalov, M. N. Kondrashova. Biochimie, 2006.
test Non-enzymatic formation of succinate under oxidative stress. N. I. Fedotcheva, A. P. Sokolov, M. N. Kondrashova. Free Radicals in Biology & Medicine, 2006, 41(1), 56-64.
test The two Krebs Cycle intermediates succinate and a-ketoglutarate: from substrates to signal molecules. M. N. Kondrashova. Chairman's Introduction on the session: Therapeutic aspects in bioenergetics, 14th European Bioenergetic Conference, Moscow, July 2006.
test Signal, sympathetic action of succinate in experimental and clinical studies. E. I. Maevsky, A. S. Rosenfeld, A. B. Peskov, M. N. Kondrashova. BBA, Supplemental volume 14, 14th EBEC Short Reports, 536-537, 2006.
test Responses of mitochondrion in immobilized lymphocyte. M. V. Zakharchenko, N. V. Chnderyakova, A. V. Zakharchenko, N. S. Katina, M. N. Kondrashova. BBA, Supplemental volume 14, 14th EBEC Short Reports, 530-531, 2006.
test The dependence of H2O2 formation in mitochondria on succinate dehydrogemase activity. R. E. Kazakof, E. G. Litvinova, N. I. Venediktova, M. N. Kondrashova, BBA, Supplemental volume 14, 14th EBEC Short Reports, 422-423, 2006.
test Non-hormonal dietary supplement that helps to manage symptoms of menopause. E.I. Maevsky, A.B. Peskov, M.L. Uchitel, A. Pogorelov, M.N. Kondrashova. Presentation at GASTRO-2007, St. Petersburg.
test Preservation of the in vivo state of mitochondrial network for ex vivo physiological study of mitochondria. M. N. Kondrashova, M. Zakharchenko, N. Khunderyakova. International Journal of Biochemistry and Cell Biology 41 (2009), 2036-2050.
test Cito-Bio-Chemical (CBCH) Assay of Mitochondrial Function in the Organism & Rejuvenating Effects of Amberen on Aging Female Rats. A.A. Vasilieva, N.V. Khunderyakova, M.V. Zakharchenko, A.V. Zakharchenko, M. A. Simonova, O.I. Romanova, E.V. Grishina , А.A. Azarashvili, A. N. Murashev, E.I. Maevsky, M.N. Kondrashova. 5th annual Assay and Drug Discovery Technologies Conference, September 20-21, 2010, San Diego, CA.